The effects of enflurane and isoflurane on the postoperative hepatic function were compared in 39 pediatric patients with preoperative mild abnormal hepatic functions.
The pediatric patients were divede randomly into two groups of enflurane(=20) and isoflurane(n=19). Anesthesia was maintained 1 MAC of each anesthetic combined with 50% oxygen and 50% nitrous oxide.
Serum glutamic-oxaloacetic transaminase(SGOT), serum glutamate pyruvate transaminase(SGPT), total bilirubin, alkaine phosphatase, eosinophil count, body temperature were measured preoperatively, and on postoperative 1 and 3 day. Authors compared
above
parameters within the group and between two groups. There were no statistically signifecant differencies in hepatic function, eosinophil count, and body temperature within the group and between two groups.
Thus, this study shows that enflurane and isoflurane would not affect hepatic function in peditric patients with mild hepatic dysfunction.
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